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promyelocytic (M3) acute leukaemia; many sufferers Convey an unusual morphologic spectrum intermediate among M2 and M3 AML.
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high fee of normal or dystrophic promyelocytes in peripheralblood and in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction favourable; immunocytochemical detection with the anti-PLZF reveals adistinct punctate nuclear distribution from the protein, suggesting itscompartmentalization from the nucleus.
Fast detection of prognostically important fusion transcripts in acute leukemia using simplified multiplex reverse transcription polymerase chain reaction.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a circumstance report and evaluation of literature.
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Prosperous allogeneic bone marrow transplantation inside of a case of variant acute promyelocytic leukemia with ZBTB16-RARA.
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A case of acute promyelocytic leukaemia with unusual cytological features and a ZBTB16-RARA fusion gene.
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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.
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the translocation consists of a breakpoint while in the zinc fingerregion of PLZF, with fusion of two zinc fingers towards the RARa B location toform a 5 PLZF - three RARa fusion gene; the reciprocal 5 RARa - three PLZF genefuses seven zinc fingers to the RARa area; RARas breakpoint occurs in1- on account of thealternative splicing of PLZF gene, two kinds of PLZF-RARa protein can be detected: